2025 Week 1 NFL picks, odds, best bets from proven model: This 5-way football parlay would return nearly 25-1 After 10,000 simulations, SportsLine's model reveals its top Week 1 NFL 25-1 football ...

All of the updated Week 1 NFL lines are listed below, and SportsLine's advanced computer model has all the NFL betting advice and NFL predictions you need to make the best Week 1 NFL picks now.