A two-stage association study is the most commonly used method to efficiently identify disease susceptibility genes. However, some recent single nucleotide polymorphism (SNP) studies recently utilized ...

For a desired power of detecting the association between a disease and several potential risk factors in case-control studies, Yang (1978, Biometrika 65, 635-640) and Halperin (1980, Biometrika 67, ...

Power and sample size calculations are critical parts of any research design for genetic association. We present a method that utilizes haplotype frequency information and average marker-marker ...

Define statistical power List the potential consequences of doing a study that has low power, and also a study that has too much power. Explain what a type 1 and type ...

Please provide your email address to receive an email when new articles are posted on . Increasing sample sizes in genetic studies, regardless of the depth of phenotyping, may help better estimate ...