Tic-tac-toe (or “Noughts and Crosses”) is a game simple enough to implement in any computer system: indeed it’s often used in beginner’s programming courses. A more challenging project ...

"Using this mechanism, we created the world's smallest game board for playing tic-tac-toe, where every move involves molecular self-reconfiguration for swapping in and out hundreds of DNA strands ...

The Tic-Tac-Toe game circumvents this complication by using a second technique called DNA strand displacement. With this approach, scientists again exploit DNA pairing patterns.

If you Google for “tic-tac-toe” or “tic tac toe,” you’ll also see a playable game in a card in the search results. You can adjust the settings here to Easy, Medium or Impossible.