Covariate-adaptive randomization represents an advanced methodology in the design of clinical trials, ensuring a balanced distribution of prognostic factors among treatment groups.

A research team analyzed linguistic approaches to help cancer patients better comprehend the concept of randomization, being assigned by chance to treatment or control groups, in clinical trials.

A technique called Mendelian randomization could be the revolutionary tool drug companies have been waiting for.

I am no stranger to the importance of randomization when conducting a study. I minored in psychology as an undergraduate, so I took part in the experimentation process--both by being experimented on ...

The concept of randomized assignment though has long been difficult for patients and their caregivers. Use of adaptive randomization in clinical trials has emerged as a potential response to this ...

Randomized clinical trials can present a scientific/ethical dilemma for clinical investigators. Statisticians have tended to focus on only one side of this dilemma, emphasizing the statistical and ...

Mendelian randomization methods A major goal of epidemiology is to reduce the burden of disease in populations through interventions that target causal determinants of disease risk. Although ...

Adaptive randomization is also relevant in phase II/III trials that address many doses and schedules of drugs and combination therapy, identifying responding subpopulations and dropping arms along the ...

Cluster randomized trials with relatively few clusters have been widely used in recent years for evaluation of health-care strategies. The balance match weighted (BMW) design, introduced in Xu and ...

This review article considers the strengths and weaknesses of randomized clinical trials that are conducted through the analysis of data gathered by health insurers.