In conclusion, researchers who perform SNP studies for identifying disease susceptibility genes need to take account of three-stage case-control association studies, corresponding to study ...

Kung-Jong Lui, Sample Size Determination for Multiple Continuous Risk Factors in Case- Control Studies, Biometrics, Vol. 49, No. 3 (Sep., 1993), pp. 873-876 ...

Power and sample size calculations are critical parts of any research design for genetic association. We present a method that utilizes haplotype frequency information and average marker-marker ...

As mentioned above, in a case-control study it is often easier to recruit more controls since we often use the case-control design to study rare outcomes. Directly following on from the previous ...

Increasing sample sizes in genetic studies, regardless of the depth of phenotyping, may help better estimate risk for depression, according to results of a case-control polygenic risk score ...